RESUMO
It is of interest to document the correlation of myeloperoxidase (MPO) and Troponin T (TnT) in young Indian patients with myocardial infarction using epidemiological data. A study with 220 (110 case and 110 control) participants with Acute Coronary Syndrome (both males and females) was completed. Patients were identified using a pre-designed PROFORMA at the OPD and IPD of the Medicine Department at the Index Medical College & Hospital, Malwanchal University and Moti Lal Nehru Medical College and Swaroop Rani Nehru Hospital in India. MPO and TnT were measured using the Sandwich ELISA (Sandwich Enzyme linked immunosorbent Assay) kit. TnT (pg/ml) (Mean ± SD) were high in the case group than control 134.7 ± 8.57 vs 96.6 ± 2.82; F = 145.9; t = 44.3; p < 0.01). Moreover, MPO was 3-fold high in case group than control (157±30.1 and 42.4±14.82, respectively). The differences was found statistically significant (p<0.001). This suggests a link between TnT and MPO among young Indian patients with myocardial infarction.
RESUMO
BACKGROUND: Chronic kidney disease (CKD) causes irreversible damage to the renal tissue resulting in decreased kidney function. It is known more for its morbidity than for its mortality as the deranged kidney functioning affects almost every organ system of the body. Dyslipidemia is one of the most common complications of chronic renal failure (CRF) reflected even in the early stages of CRF and usually parallels the deterioration in renal function. As a consequence, dyslipidemia as a risk factor in CKD progression should be explored and documented more. The aim of the study was to compare the pattern of lipid profile in CKD patients on conservative management with that of CKD patients on hemodialysis. MATERIALS AND METHODS: This is a cross-sectional observational study conducted in Lucknow, India, between January 2021 to May 2021 after considering inclusion and exclusion criteria. The lipid profile of 105 eligible patients was analyzed using an autoanalyzer. After generation of the proper template, data was entered in Microsoft Excel (Microsoft Corp., Redmond, Washington, United States) and analysis was done through SPSS for Windows, Version 16.0 (Released 2007, SPSS Inc., Chicago, United States). RESULTS: There was a statistically significant decrease in high-density lipoprotein (HDL) and an increase in triglycerides (TG) and very-low-density lipoprotein (VLDL) levels in CKD patients on hemodialysis when compared with CKD patients on conservative management. As far as total cholesterol and low-density lipoprotein (LDL) levels are concerned, they were also significantly increased in CKD patients on hemodialysis than CKD patients on conservative management. CONCLUSIONS: Dyslipidemia progresses with the stage of CKD, so early monitoring of lipid profile in CKD patients may help in decreasing the progression of the disease and, hence, mortality in CKD patients.
RESUMO
It is of interest to document the point-of-care test using heart-type fatty-acid binding protein (H-FABP) in comparison with CK-MB, Troponin T and hsCRP. This is a more sensitive and specific cardiac biomarker than cTnT and CK-MB, and it has a higher diagnostic effectiveness for detecting early acute myocardial infarction (AMI). The case-control study enrolled 220 participants (110 myocardial infarction patients as cases and 110 healthy subjects as control) > 18 years of either sex after ethical clearance and informed consent form. The study conducted was conducted in the OPD and IPD of Medicine and Biochemistry Department at Moti Lal Nehru Medical College and Swaroop Rani Nehru Hospital Prayagraj, Uttar Pradesh; Index Medical College & Hospital, Malwanchal University, India. The amount of H-FABP, CKMB and cTnT was measured using the Sandwich ELISA method and hs-CRP was evaluated using the immune-turbidimetry method. H-FABP correlation with selected markers (CK-MB, hs CRP and TnT) and CK-MB was significant. A positive correlation (r=0.2 to 0.29) was found when H-FABP was compared with CK-MB (p<0.05). Similar positive correlation was found in CK-MB with cTnT. H-FABP is a useful cardiac marker for the early diagnosis of young AMI and thus prediction of myocardial injury is possible. H-FABP compared with CK-MB showed positive correlation. CK-MB with cTnT also showed statistically significant relation. Thus, H-FABP and CK-MB, as well as the correlation between CK-MB and TnT, reflects utility in early-stage diagnosis of myocardial injury.
RESUMO
BACKGROUND: Chronic kidney disease (CKD) patients are at elevated risk of cardiovascular diseases (CVD) due to altered lipid profiles. Dyslipidemia is maximal in end stage renal disease (ESRD) patients and there is insufficient data on the impact of hemodialysis on lipid profile. The present study was aimed to evaluate the effect of hemodialysis on lipid profile of CKD patients. MATERIALS AND METHODS: This cross-sectional study was conducted on 50 CKD patients on hemodialysis from three randomly selected hospitals of Lucknow, Uttar Pradesh, India, between March - May 2021. Serum lipid profile was analysed before and after hemodialysis session by using an auto analyzer. The mean values of different lipid parameters before and after hemodialysis were calculated and the difference between them was analyzed by using paired t-test. A p-value of <0.05 was considered to be statistically significant. RESULTS: In this study, very low density lipoprotein (VLDL) levels decreased significantly after hemodialysis. Total cholesterol (TC), low density lipoprotein (LDL) and triglyceride (TG) levels were also significantly lowered. High density lipoprotein (HDL) was the only lipoprotein that increased after dialysis although this increase was non-significant. CONCLUSION: Adequate dialysis and time bound monitoring of various components of lipid profile can help CKD patients by decreasing risks for cardiovascular complications.
